Intrabronchial application of extracellular histones shows no proinflammatory effects in swine in a translational pilot study

Abstract Objective Extracellular histones have been identified as one molecular factor that can cause and sustain alveolar damage were linked to high mortality rates in critically ill patients. In this pilot study, we wanted validate the proinflammatory vivo effects of local histone application a prospective translational porcine model. This was combined with evaluation an experimental acute lung injury model using intrabronchial lipopolysaccharides, which has published previously. Results The targeted successful all animals. Animals showed decreased oxygenation after instillation, but no differences could be detected between sham treatments. histologic analyses inflammatory responses indicated there tissue groups.